机构：[1]Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院[2]Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属协和医院[3]Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China江苏省人民医院[4]International Centre for Allergy Research, Nanjing Medical University, Nanjing, China[5]Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China[6]Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[7]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[8]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China首都医科大学附属北京同仁医院研究所耳鼻咽喉科研究所[9]Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China中山大学附属第一医院[10]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China[11]Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China首都医科大学附属安贞医院[12]Otorhinolaryngology Hospital, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China[13]Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China[14]Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China中山大学附属第三医院[15]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[16]Department of Otolaryngology Head and Neck Surgery, The Second Hospital, Shanxi Medical University, Taiyuan, China[17]Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China吉林大学中日联谊医院[18]Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, China
The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese population differ from those observed in the populations of European descent. Recently, precision medicine has been used to treat inflammation by targeting key biomarkers that are involved in the process. However, there are no CRS guidelines or a consensus available from China that can be shared with the international academia. The guidelines presented in this paper cover the epidemiology, economic burden, genetics and epigenetics, mechanisms, phenotypes and endotypes, diagnosis and differential diagnosis, management, and the current status of CRS in China. These guidelines-with a focus on China-will improve the abilities of clinical and medical staff during the treatment of CRS. Additionally, they will help international agencies in improving the verification of CRS endotypes, mapping of eosinophilic shifts, the identification of suitable biomarkers for endotyping, and predicting responses to therapies. In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes.
第一作者机构：[1]Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
共同第一作者：
通讯作者：
通讯机构：[7]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China[8]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China[15]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China[*1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China[*2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Liu Zheng,Chen Jianjun,Cheng Lei,et al.Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis[J].ALLERGY ASTHMA & IMMUNOLOGY RESEARCH.2020,12(2):176-237.doi:10.4168/aair.2020.12.2.176.
APA：
Liu, Zheng,Chen, Jianjun,Cheng, Lei,Li, Huabin,Liu, Shixi...&Zhang, Luo.(2020).Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.ALLERGY ASTHMA & IMMUNOLOGY RESEARCH,12,(2)
MLA：
Liu, Zheng,et al."Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis".ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 12..2(2020):176-237
