Purpose: Previous studies have shown brain reorganizations after early deprivation of auditory sensory. However, changes of grey matter connectivity have not been investigated in prelingually deaf adolescents yet. In the present study, we aimed to investigate changes of grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents. Methods: We recruited 16 prelingually deaf adolescents and 16 age- and gender-matched normal controls, and extracted the grey matter volume as the structural characteristic from 14 regions of interest involved in auditory, language or visual processing to investigate the changes of grey matter connectivity within and between auditory, language and visual systems. Sparse inverse covariance estimation (SICE) was utilized to construct grey matter connectivity between these brain regions. Results: The results show that prelingually deaf adolescents present weaker grey matter connectivity within auditory and visual systems, and connectivity between language and visual systems declined. Notably, significantly increased brain connectivity was found between auditory and visual systems in prelingually deaf adolescents. Conclusions: Our results indicate "cross-modal" plasticity after deprivation of the auditory input in prelingually deaf adolescents, especially between auditory and visual systems. Besides, auditory deprivation and visual deficits might affect the connectivity pattern within language and visual systems in prelingually deaf adolescents.
基金：
863 Project (2013
AA013803), National Natural Science Foundation of
China (NSFC) (No. 81271557, No. 61271151, No.
61228103), the Beijing Postdoctoral Research Foundation (No. 2014ZZ-8) and Doctoral Scientific Research
Foundation of Beijing University of Technology, We
thank all the subjects and their families for the time
and effort they dedicate to our research.
第一作者机构：[1]Beijing Univ Technol, Coll Elect & Control Engn, Beijing, Peoples R China[2]Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China[3]Beijing Key Lab Computat Intelligence & Intellige, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China[4]Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China[*1]State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences[*2]Department of Radiology, Beijing Tongren Hospital, Capital Medical University
推荐引用方式(GB/T 7714)：
Li Wenjing,Li Jianhong,Wang Zhenchang,et al.Grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents[J].RESTORATIVE NEUROLOGY AND NEUROSCIENCE.2015,33(3):279-290.doi:10.3233/RNN-140437.
APA：
Li, Wenjing,Li, Jianhong,Wang, Zhenchang,Li, Yong,Liu, Zhaohui...&He, Huiguang.(2015).Grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents.RESTORATIVE NEUROLOGY AND NEUROSCIENCE,33,(3)
MLA：
Li, Wenjing,et al."Grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents".RESTORATIVE NEUROLOGY AND NEUROSCIENCE 33..3(2015):279-290
