机构：[1]Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China[2]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiaotong University School of Medicine, Shanghai, China[3]Digestive Endoscopy Center, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
The LIM protein Ajuba contains an unstructured proline/glycine-rich preLIM region in the N terminus and conserved tandem LIM motifs in the C terminus. Additionally, Ajuba contains both nuclear export sequences (NES) and nuclear localization sequences (NLS), which enable Ajuba shuttle between the cytoplasm and the nucleus. Thus, Ajuba can act as a versatile scaffold participating in assembly of variety of protein complexes to execute multiple cellular functions including cell adhesion, motility, mitosis, survival, gene expression, microRNA processing and mechanical force sensing. Numerous studies have demonstrated that Ajuba plays important roles in oncogenesis and progression by regulating major signalling pathways such as Wnt, RAS/ERK, JAK/STAT and Hippo, and by acting as a co-regulator of key transcription factors such as Snail, Spl and nuclear hormone receptors. Clinically, Ajuba is highly expressed in various types of tumors and can be a marker for prognosis and diagnosis. In this review, we aim to summarize the up-to-date literatures on the signaling pathways mediated by Ajuba and its associated protein complexes in oncogenesis, and to discuss Ajuba as a potential target for new therapeutics to treat cancers.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872131, 31671415, 31601114, 31970679]; Shanghai Rising-Star Program [19QA1405000]; Shanghai talent development [2017034]; Shanghai Committee of Science and TechnologyShanghai Science & Technology Committee [18ZR1434900]
第一作者机构：[1]Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China[2]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiaotong University School of Medicine, Shanghai, China[*1]280 South Chongqing Rd, Building 7#, Room 110, Shanghai, 200025, China.
通讯作者：
通讯机构：[1]Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China[2]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiaotong University School of Medicine, Shanghai, China[3]Digestive Endoscopy Center, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China[*1]280 South Chongqing Rd, Building 7#, Room 110, Shanghai, 200025, China.[*2]1111 Xianxia Rd, Shanghai, China.[*3]280 South Chongqing Rd, Building 7#, Room 110, Shanghai, 200025, China.
推荐引用方式(GB/T 7714)：
Jia Hao,Peng Haixia,Hou Zhaoyuan.Ajuba: An emerging signal transducer in oncogenesis[J].PHARMACOLOGICAL RESEARCH.2020,151:doi:10.1016/j.phrs.2019.104546.
APA：
Jia, Hao,Peng, Haixia&Hou, Zhaoyuan.(2020).Ajuba: An emerging signal transducer in oncogenesis.PHARMACOLOGICAL RESEARCH,151,
MLA：
Jia, Hao,et al."Ajuba: An emerging signal transducer in oncogenesis".PHARMACOLOGICAL RESEARCH 151.(2020)
医学