机构：[1]Women's Hospital of Nanjing Medical University, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China[2]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Interest in the high folate status of pregnant women has increased due to its role in the prevention of neural tube defects (NTDs). The effect of increased red blood cell (RBC) folate status during the second trimester of pregnancy on gestational diabetes mellitus (GDM) remains unclear. We measured RBC folate concentrations by competitive protein-binding assay and obtained clinical information from electronic medical records. Logistic regression analysis was used to explore the associations of RBC folate concentrations with risks of gestational diabetes mellitus (GDM). We further assessed the potential nonlinear relations between continuous log-transformed RBC folate concentrations and GDM risk by using the restricted cubic splines. We observed high RBC folate concentrations in GDM patients compared to control group [median (interquartile range, IQR), GDM vs. controls: 1,554.03 (1,240.54-1,949.99) vs. 1,478.83 (1,124.60-1,865.71) nmol/L, p = .001]. Notably, high folate concentrations were significantly associated with an increased risk of GDM [RR per 1-SD increase: 1.16 (1.03, 1.30), p = .012] after adjustment for maternal age, parity, and body mass index (BMI) at enrollment. In the restricted cubic spline model, a test of the null hypothesis of the linear relationship was rejected (p = .001). Our study firstly showed that maternal RBC folate concentrations during the second trimester of pregnancy increase the risk of GDM in a Chinese population. Further randomized clinical trials (RCTs) are warranted to confirm the adverse effect.
基金：
National Natural Science Foundation of
China, Grant/Award Number: 81770866,
81702569 and 81701491; Jiangsu Provincial
Medical Innovation Team, Grant/Award
Number: CXTDA2017001; Jiangsu
Provincial Medical Youth Talent, Grant/
Award Number: QNRC2016108; Jiangsu
Province Natural Science Foundation,
Grant/Award Number: BK20170151 and
BK20170152; Jiangsu Provincial Key
Research and Development program,
Grant/Award Number: BE2018614 and
BE2018616; Nanjing Medical Science and
Technique Development Foundation, Grant/
Award Number: JQX18009
第一作者机构：[1]Women's Hospital of Nanjing Medical University, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
共同第一作者：
通讯作者：
通讯机构：[1]Women's Hospital of Nanjing Medical University, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China[2]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[*1]Women's Hospital of Nanjing Medical University, Nanjing, China
推荐引用方式(GB/T 7714)：
Xie Kaipeng,Xu Pengfei,Fu Ziyi,et al.Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus[J].FOOD SCIENCE & NUTRITION.2019,7(11):3759-3765.doi:10.1002/fsn3.1235.
APA：
Xie, Kaipeng,Xu, Pengfei,Fu, Ziyi,Gu, Xiaohong,Li, Hui...&Guo, Xirong.(2019).Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus.FOOD SCIENCE & NUTRITION,7,(11)
MLA：
Xie, Kaipeng,et al."Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus".FOOD SCIENCE & NUTRITION 7..11(2019):3759-3765
