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Quinacrine Depletes BCR-ABL and Suppresses Ph-Positive Leukemia Cells

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收录情况： ◇ SCIE

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机构： [1]Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Hongqiao Int Inst,Shanghai Univ E Inst,Natl Minis, Fac Basic Med,Shanghai Tongren Hosp,Sch Med,Chem, Shanghai 200025, Peoples R China [2]Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Shanghai, Peoples R China [3]Shanghai Jiao Tong Univ, Sch Med, Dept Hematol, Ruijin Hosp, Shanghai 200025, Peoples R China

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关键词： Quinacrine BCR-ABL RNA polymerase I CML

摘要：

Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34(+) progenitor/stem leukemia cells from CML patients. QC targets RNA polymerase I, which produces ribosomal (r)RNA, involving in protein translation process. Also, QC treatment prolongs CML-like mice survival and inhibits K562 tumor growth in vivo. In conclusion, we demonstrate that QC depletes BCR-ABL protein and suppresses Ph-positive leukemia cells in vitro and in vivo.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2017]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 1.8 最新[2023版] 2.1 最新五年平均 2.053 出版当年[2017版] 2.151 出版当年五年平均 2.007 出版前一年[2016版] 1.962 出版后一年[2018版]

第一作者：

第一作者机构： [1]Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Hongqiao Int Inst,Shanghai Univ E Inst,Natl Minis, Fac Basic Med,Shanghai Tongren Hosp,Sch Med,Chem, Shanghai 200025, Peoples R China

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通讯作者：

通讯机构： [1]Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Hongqiao Int Inst,Shanghai Univ E Inst,Natl Minis, Fac Basic Med,Shanghai Tongren Hosp,Sch Med,Chem, Shanghai 200025, Peoples R China [3]Shanghai Jiao Tong Univ, Sch Med, Dept Hematol, Ruijin Hosp, Shanghai 200025, Peoples R China [*1]Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [*2]Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities EInstitutes, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

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