机构：[1]Shanghai Changning Maternity and Infant Health Hospital, Shanghai, China[2]Institutes of Biomedical Sciences, Fudan University, Shanghai, China[3]International Peace Maternity & Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai Key Laboratory for Reproductive Medicine, Shanghai, China[4]Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[5]Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China[6]State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China[7]Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China[8]Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
Endometriosis is a benign disease, with malignant properties. A necessary step in the progression of endometriosis is tissue remodeling, which is coordinated by the activities of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs). This study evaluated the regulation of abnormal MMP and TIMP gene expression during endometriosis. Among the two genes families, promoter regions of MMP2, MMP3, MMP7, TIMP3, and TIMP4 were significantly altered in proliferative-phase endometriotic lesions compared to menstrual cycle-matched eutopic tissue from endometriosis-free women. In addition, a negative correlation was found between the DNA methylation status of the promoter region and transcript abundance of MMP2. Our findings suggest that changes in DNA methylation at the promoter region of MMP2 could underlie the changes in its expression in the ectopic endometria from patients with endometriosis.
基金：
The National Basic Research Program of China,
Grant number: 2015CB943300; Shanghai
Changning district Public Health Bureau
Research Program of China, Grant number:
20114Y01003; Shanghai Municipal Commission
of Science and Technology Program of China,
Grant numbers: 14DJ1400101, 17ZR1401900;
National Natural Science Foundation of China,
Grant number: 81501276; Shanghai Municipal
Commission of Health and Family Planning
Program of China, Grant number: 20154Y0039;
Shanghai Jiao Tong University Program of
China, Grant number: YG2014MS34
第一作者机构：[1]Shanghai Changning Maternity and Infant Health Hospital, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[2]Institutes of Biomedical Sciences, Fudan University, Shanghai, China[6]State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China[8]Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China[*1]Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China.[*2]Institutes of Biomedical Sciences.State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200032, China.
推荐引用方式(GB/T 7714)：
Tang Longying,Xiang Yuqian,Zhou Yaohua,et al.The DNA methylation status of genes encoding Matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis[J].MOLECULAR REPRODUCTION AND DEVELOPMENT.2018,85(1):17-25.doi:10.1002/mrd.22931.
APA：
Tang, Longying,Xiang, Yuqian,Zhou, Yaohua,Mu, Jian,Zai, Meiqing...&Li, Qiaoli.(2018).The DNA methylation status of genes encoding Matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis.MOLECULAR REPRODUCTION AND DEVELOPMENT,85,(1)
MLA：
Tang, Longying,et al."The DNA methylation status of genes encoding Matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis".MOLECULAR REPRODUCTION AND DEVELOPMENT 85..1(2018):17-25
