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Overexpression of thymic stromal lymphopoietin in allergic rhinitis

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Otolaryngology, Hainan Provincial People’s Hospital, HaiKou, China [2]Department of Surgery, Union Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China [3]Department of Otolaryngology Headand Neck Surgery, Tongren Hospital, Capital Medical University, Beijing, China

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关键词： Allergic rhinitis thymic stromal lymphopoietin T cell cytokine interleukin-4

摘要：

Conclusion. Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR. Objective. To evaluate the possible role of TSLP in the pathogenesis of AR. Patients and methods. We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA). Results. TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P0.05).

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出版当年[2008]版：

大类 | 4 区医学

小类 | 4 区耳鼻喉科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区耳鼻喉科学

JCR分区：

出版当年[2007]版：

Q3 OTORHINOLARYNGOLOGY

最新[2023]版：

Q3 OTORHINOLARYNGOLOGY

影响因子： 1.2 最新[2023版] 1.4 最新五年平均 0.983 出版当年[2007版] 1.072 出版当年五年平均 0.738 出版前一年[2006版] 0.868 出版后一年[2008版]

第一作者：

第一作者机构： [1]Department of Otolaryngology, Hainan Provincial People’s Hospital, HaiKou, China

通讯作者：

通讯机构： [3]Department of Otolaryngology Headand Neck Surgery, Tongren Hospital, Capital Medical University, Beijing, China [*1]Department of Otolaryngology Head and Neck Surgery, Tongren Hospital, Capital Medical University, Beijing, China

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