Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness, Functional Subzones, and Macular Ganglion Cell-Inner Plexiform Layer in Differentiating Patients With Mild, Moderate, and Severe Open-angle Glaucoma
机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Institute of Ophthalmology, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Queensland Eye Institute[4]University of Queensland, Brisbane, Australia.
Precis: Based on 6 functional subzones of peripapillary retinal nerve fiber layer (pRNFL) thickness, the glaucoma detection ability of zone 2 and zone 4 was high and comparable with that of mean pRNFL in glaucoma groups. Purpose: To compare diagnostic performance of pRNFL subzones, mean pRNFL thickness, and macular ganglion cell-inner plexiform layer (mGCIPL) in mild, moderate, and severe open-angle glaucoma. Materials and Methods: One hundred eighty-one patients with open-angle glaucoma (318 eyes: 122 mild, 60 moderate, and 136 severe glaucoma) and 70 normal subjects underwent spectral-domain optical coherence tomography measurements. FORUM software was used to determine subzone pRNFL thickness mapping the visual field to the optic disc (6 zones). The thickness and area under the receiver operating curve (AUROC) of each parameter were compared between groups. DeLong's method was used to compare AUROCs between mean pRNFL and mGCIPL and each zone of spectral-domain optical coherence tomography parameters. Results: Mean pRNFL thickness (99.81 +/- 10.06 mu m) and mGCIPL thickness (83.24 +/- 5.91 mu m) were higher in controls compared with glaucoma (67.42 +/- 13.22 and 63.31 +/- 10.85 mu m;P<0.001). Mean pRNFL had the best diagnostic performance in mild (0.957) and severe (1.000) glaucoma. Of the 6 zonal parameters, zone 2 (associated with the inferior temporal sector) best discriminated glaucomatous changes between controls and mild and moderate (0.941 and 0.988). Zone 4 (associated with the superior temporal sector) best discriminated glaucomatous changes between controls and severe glaucoma (0.998). AUROCs for zone 2 and zone 4 were not significantly different from mean pRNFL and mGCIPL in all glaucoma groups (allP>0.0038). Conclusions: Mean pRNFL had the best diagnostic performance in mild and severe glaucoma. Glaucoma detection ability of zone 2 and zone 4 was high and comparable with that of mean pRNFL and mGCIPL in all glaucoma groups.
基金：
National Nature Science Foundation of
China 11571031
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab
通讯作者：
通讯机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab[2]Beijing Institute of Ophthalmology, Beijing, China[*1]Beijing Tongren Eye Center/Beijing Tongren Hospital, Capital Medical University, No. 1 Dong Jiao Min Xiang Street, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Huo Yan Jiao,Thomas Ravi,Li Lei,et al.Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness, Functional Subzones, and Macular Ganglion Cell-Inner Plexiform Layer in Differentiating Patients With Mild, Moderate, and Severe Open-angle Glaucoma[J].JOURNAL OF GLAUCOMA.2020,29(9):761-766.doi:10.1097/IJG.0000000000001598.
APA：
Huo, Yan Jiao,Thomas, Ravi,Li, Lei,Cao, Kai,Wang, Huai Zhou&Wang, Ning Li.(2020).Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness, Functional Subzones, and Macular Ganglion Cell-Inner Plexiform Layer in Differentiating Patients With Mild, Moderate, and Severe Open-angle Glaucoma.JOURNAL OF GLAUCOMA,29,(9)
MLA：
Huo, Yan Jiao,et al."Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness, Functional Subzones, and Macular Ganglion Cell-Inner Plexiform Layer in Differentiating Patients With Mild, Moderate, and Severe Open-angle Glaucoma".JOURNAL OF GLAUCOMA 29..9(2020):761-766
