机构：[1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing, China临床科室耳鼻咽喉-头颈外科研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
Chronic rhinosinusitis with nasal polyps (CRSwNP), a type 2-based upper airway disease, is mainly characterized by high asthma comorbidity and recurrence after surgery. It has been shown that type 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13 released from T helper 2 (Th2) cells as well as group 2 innate lymphoid cells (ILC2s), contribute to chronic inflammation of CRSwNP. This review summarizes recent progresses made in our understanding of ILC2 activity, particularly ILC2 accumulation at airway inflammation sites, cooperation with Th2 cells in aggravating the CRSwNP inflammatory process and interactions with regulatory T cells (Tregs) in resisting Tregs-mediated suppressive function in allergic inflammation. A better understanding of the biology of ILC2s should lay a good foundation in elucidating the pathogenesis of CRSwNP, and subsequently may lead to the development of new therapeutic strategies for the management of CRSwNP.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81700026]; Public Welfare Development and Reform Pilot Project [2019-10]; Beijing Municipal Administration of Hospital's Youth Programme [QML20180201]; priming scientific research foundation for the junior researcher in Beijing Tongren Hospital, Capital Medical University
第一作者机构：[1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing, China
通讯作者：
通讯机构：[1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing, China[*1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, No.17, Hougou Hutong, Dongcheng Beijing Institute of Otolaryngology, District, Beijing 100730, China.[*2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, No.17, Hougou Hutong, Dongcheng District, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Li Yan,Wang Wei,Ying Sun,et al.A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps[J].ALLERGY ASTHMA & IMMUNOLOGY RESEARCH.2021,13(3):363-374.doi:10.4168/aair.2021.13.3.363.
APA：
Li, Yan,Wang, Wei,Ying, Sun,Lan, Feng&Zhang, Luo.(2021).A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.ALLERGY ASTHMA & IMMUNOLOGY RESEARCH,13,(3)
MLA：
Li, Yan,et al."A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps".ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 13..3(2021):363-374
