Objective: The present study compared the effectiveness of asthma control test (ACT)-guided treatment vs. usual care (UC) in patients with asthma from China. Methods: This prospective, phase IV, multicenter, cluster-randomized, open-label 24-week study was conducted in China; patients were randomized to either ACT-guided treatment or UC group. The patients recorded peak expiratory flow, symptoms, and medication in a diary card every day and completed ACT at every clinic visit. For the UC group, patients completed ACT after the physician's treatment decision. Results: In total, 83.6% patients (n = 443/530; ACT: n = 209, UC: n = 234) completed the study. A significantly higher proportion of patients (adjusted OR [95% CI]: 7.87 (1.29, 48.11; p = 0.027) responded to the treatment and had ACT total score >= 20 or demonstrated an improvement of >3 points in ACT total score in >= 1 post-baseline assessment in the ACT-guided treatment vs. UC group. A higher proportion of patients had an ACT total score >= 20 and an improvement of >3 points in ACT total score at Week 24 in the ACT-guided treatment vs. the UC group (adjusted OR (95% CI):2.28 (1.07, 4.85; p = 0.036). A significant difference (p = 0.005) in change from baseline in ACT total score was observed in ACT-guided treatment vs. UC group at Week 24. The mean annual exacerbation rate was similar in both the groups. Conclusions: ACT-guided treatment was more effective in achieving ACT total score >= 20 or showing an improvement of >3 points in the ACT total score and well tolerated compared with UC treatment in the 24-week treatment period.
基金：
GSK (China) RD Limited [201097]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区医学
小类|3 区心脏和心血管系统3 区呼吸系统
最新[2023]版：
大类|3 区医学
小类|3 区心脏和心血管系统3 区呼吸系统
JCR分区：
出版当年[2019]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ2RESPIRATORY SYSTEM
最新[2023]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ2RESPIRATORY SYSTEM
第一作者机构：[1]Fudan Univ, Zhongshan Hosp, Shanghai 200032, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Fudan Univ, Zhongshan Hosp, Shanghai 200032, Peoples R China[*1]Zhongshan hospital, Fudan University, Shanghai, 200032, China
推荐引用方式(GB/T 7714)：
Ye Ling,Gao Xiwen,Tu Chunlin,et al.Comparative analysis of effectiveness of asthma control test-guided treatment versus usual care in patients with asthma from China[J].RESPIRATORY MEDICINE.2021,182:doi:10.1016/j.rmed.2021.106382.
APA：
Ye, Ling,Gao, Xiwen,Tu, Chunlin,Du, Chunling,Gu, Wenchao...&Jin, Meiling.(2021).Comparative analysis of effectiveness of asthma control test-guided treatment versus usual care in patients with asthma from China.RESPIRATORY MEDICINE,182,
MLA：
Ye, Ling,et al."Comparative analysis of effectiveness of asthma control test-guided treatment versus usual care in patients with asthma from China".RESPIRATORY MEDICINE 182.(2021)
