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Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies.

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收录情况： ◇ SCIE ◇ SSCI

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机构： [a]Beijing Tongren Hospital, Capital Medical University, Beijing, China [b]Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China [c]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [d]Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil [e]Endocrinology and Nutrition Department, Hospital Universitari Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut Recerca (VHIR), Universitat Aut`onoma de Barcelona, Passeig de la Vall d’Hebron, 119. 08035, Barcelona, Spain [f]Centro de Investigaci´on Biom´edica en Red de Diabetes y Enfermedades Metab´olicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

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关键词： Body mass index Waist circumference Waist-to-hip ratio Structural brain abnormalities

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We aimed to evaluate the relationship between obesity and structural brain abnormalities assessed by magnetic resonance imaging using data from 45 observational epidemiological studies, where five articles reported prospective longitudinal results. In cross-sectional studies' analyses, the pooled weighted mean difference for total brain volume (TBV) and gray matter volume (GMV) in obese/overweight participants was -11.59 (95 % CI: -23.17 to -0.02) and -10.98 (95 % CI: -20.78 to -1.18), respectively. TBV was adversely associated with BMI and WC, GMV with BMI, and hippocampal volume with BMI, WC, and WHR. WC/WHR are associated with a risk of lacunar and white matter hyperintensity (WMH). In longitudinal studies' analyses, BMI was not statistically associated with the overall structural brain abnormalities (for continuous BMI: RR = 1.02, 95 % CI: 0.94-1.12; for categorial BMI: RR = 1.18, 95 % CI: 0.75-1.85). Small sample size of prospective longitudinal studies limited the power of its pooled estimates. A higher BMI is associated with lower brain volume while greater WC/WHR, but not BMI, is related to a risk of lacunar infarct and WMH. Future longitudinal research is needed to further elucidate the specific causal relationships and explore preventive measures.Copyright © 2021 Elsevier B.V. All rights reserved.

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出版当年[2020]版中科院分区表Review为是的期刊

：

大类 | 1 区

医学

小类 | 1 区老年医学 2 区细胞生物学

最新[2023]版

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大类 | 1 区

医学

小类 | 1 区老年医学 2 区细胞生物学

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出版当年[2019]版：

Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY

影响因子： 12.5 最新[2023版] 13 最新五年平均 10.616 出版当年[2019版] 10.404 出版当年五年平均 10.39 出版前一年[2018版] 10.895 出版后一年[2020版]

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第一作者机构： [a]Beijing Tongren Hospital, Capital Medical University, Beijing, China

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