机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
Allergen immunotherapy (AIT) is the only disease-modifying treatment for patients with IgE-mediated allergic diseases. Successful AIT can induce long-term immune tolerance to the common allergen, which provides clinical benefits for years after discontinuation. The cytokine interleukin (IL)-10, as a key anti-inflammatory mediator with strong immunoregulatory functions, has drawn increasing attention over the past decades.After an extensive search of PubMed, EMBASE, and Web of Science databases, covering articles published from 1989 to 2024, our review aims to emphasize the key common information from previous reviews on the crucial involvement of IL-10 in allergen immunotherapy (AIT) induced immunological tolerance. In this review, we discuss the regulation of IL-10 expression and the molecular pathways associated with IL-10 function. We also further summarize mechanisms of immune tolerance induced by AIT, especially the indispensable role of IL-10 in AIT.IL-10 plays an indispensable role in immune tolerance induced by AIT. Understanding the importance of the role of IL-10 in AIT would help us comprehend the mechanisms thoroughly and develop targeted therapeutics for allergic diseases.
基金：
This manuscript was funded by grants from the national key R&D program
of China [2022YFC2504100], the program for the Changjiang scholars and
innovative research team (IRT13082), Natural Science Foundation of China
[82371115, 82025010, 82071022 and 82271141], CAMS innovation fund
for medical sciences (2019-I2M-5-022], Beijing Municipal Science &
Technology Commission [Z211100002921057 and Z211100002921060],
Capital’s funds for health improvement and research (2022-1-1091) and
Beijing Municipal Public Welfare Development and Reform Pilot Project for
Medical Research Institutes[JYY2021-2].
第一作者机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[2]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[3]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[2]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[3]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.[*1]Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, No.1, DongJiaominxiang, DongCheng District, Beijing 100730, P.R. China
推荐引用方式(GB/T 7714)：
Liu Shixian,Li Jingyun,Zhang Yuan,et al.IL-10: the master immunomodulatory cytokine in allergen immunotherapy[J].Expert Review Of Clinical Immunology.2024,1-12.doi:10.1080/1744666X.2024.2406894.
APA：
Liu Shixian,Li Jingyun,Zhang Yuan,Wang Chengshuo&Zhang Luo.(2024).IL-10: the master immunomodulatory cytokine in allergen immunotherapy.Expert Review Of Clinical Immunology,,
MLA：
Liu Shixian,et al."IL-10: the master immunomodulatory cytokine in allergen immunotherapy".Expert Review Of Clinical Immunology .(2024):1-12
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