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Advances and highlights in biomarkers of allergic diseases

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机构: [1]Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland [2]Marmara Univ, Sch Med, Div Pediat Allergy & Immunol, Istanbul, Turkey [3]Adnan Menderes Univ, Fac Med, Dept Med Microbiol, Aydin, Turkey [4]Bursa Uludag Univ, Fac Vet Med, Dept Microbiol, Bursa, Turkey [5]Swiss Inst Bioinformat SIB, Davos, Switzerland [6]Bursa Uludag Univ, Inst Hlth Sci, Dept Med Immunol, Bursa, Turkey [7]Univ Malaga, Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain [8]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China [9]Sun Yat Sen Univ, Otorhinolaryngol Hosp, Affiliated Hosp 1, Guangzhou, Peoples R China [10]Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland [11]CEU Univ, Univ San Pablo CEU, Fac Med, Inst Appl Mol Med IMMA,Dept Basic Med Sci, Madrid, Spain [12]CEU Univ, Univ San Pablo CEU, Fac Farm, Ctr Metabol & Bioanal CEMBIO,Dept Chem & Biochem, Madrid, Spain [13]AO Res Inst Davos, Davos Pl, Davos, Switzerland [14]Univ Zurich, Fac Med, Zurich, Switzerland [15]Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland [16]Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China
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关键词: allergen immunotherapy allergic diseases biomarkers COVID-19 precision medicine

摘要:
During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of allergic diseases is characterized by a type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies. The availability of powerful omics technologies, together with integrated data analysis and network-based approaches can help the identification of clinically useful biomarkers. These biomarkers need to be accurately quantified using robust and reproducible methods, such as reliable and point-of-care systems. Ideally, samples should be collected using quick, cost-efficient and noninvasive methods. In recent years, a plethora of research has been directed toward finding novel biomarkers of allergic diseases. Promising biomarkers of type 2 allergic diseases include sputum eosinophils, serum periostin and exhaled nitric oxide. Several other biomarkers, such as pro-inflammatory mediators, miRNAs, eicosanoid molecules, epithelial barrier integrity, and microbiota changes are useful for diagnosis and monitoring of allergic diseases and can be quantified in serum, body fluids and exhaled air. Herein, we review recent studies on biomarkers for the diagnosis and treatment of asthma, chronic urticaria, atopic dermatitis, allergic rhinitis, chronic rhinosinusitis, food allergies, anaphylaxis, drug hypersensitivity and allergen immunotherapy. In addition, we discuss COVID-19 and allergic diseases within the perspective of biomarkers and recommendations on the management of allergic and asthmatic patients during the COVID-19 pandemic.

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出版当年[2020]版:
大类 | 1 区 医学
小类 | 2 区 过敏 2 区 免疫学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 免疫学 2 区 过敏
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出版当年[2019]版:
Q1 IMMUNOLOGY Q1 ALLERGY
最新[2023]版:
Q1 ALLERGY Q1 IMMUNOLOGY

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第一作者机构: [1]Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland [2]Marmara Univ, Sch Med, Div Pediat Allergy & Immunol, Istanbul, Turkey
通讯作者:
通讯机构: [1]Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland [10]Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland [*1]Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Herman Burchard Str 9, CH-7265 Davos, Switzerland
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