机构：[1]Peking Union Medical College Hospital, Beijing 100730, China[2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China[3]School of Biomedical Engineering, Capital Medical University, Beijing 100069, China[4]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[5]Department of Ophthalmology, Xuzhou First People’s Hospital, Xuzhou 221002, China
Purpose: To analyze the influence of dextran solution and corneal collagen crosslinking (CXL) on corneal biomechanical parameters in vitro, evaluated by Corneal Visualization Scheimpflug Technology (Corvis ST). Materials and Methods: Forty porcine eyes were included in this study. Twenty porcine eyes were instilled with dextran solution for 30 min (10 eyes in 2% dextran solution and 10 eyes in 20% dextran solution). CXL treatment was performed in 10 porcine eyes; the other 10 porcine eyes were regarded as the control group. Each eye was fixed on an experimental inflation platform to carry out Corvis measurements at different IOPs. Corneal biomechanical parameters were calculated based on Corvis measurement. Statistical analysis was used to analyze the influence of dextran solution and CXL on corneal biomechanical parameters based on Corvis parameters. Results: The corneal energy-absorbed area (Aabsorbed) decreased after being instilled with dextran solution under IOP of 15 mmHg (p < 0.001); the elastic modulus (E) of the cornea instilled with 20% dextran solution was significantly higher than that instilled with 2% dextran solution (p < 0.001), since it decreased after being instilled with 20% dextran solution (p = 0.030); the stiffness parameter at the first applanation (SP-A1) increased after CXL (p < 0.001). Conclusions: Both dextran solution and CXL can change corneal biomechanical properties; the concentration of dextran solution can influence the corneal biomechanical properties, which may, in turn, affect the effectiveness of CXL. SP-A1 may be used as an effective parameter for the evaluation of CXL.
基金：
This research was supported by grants from the National Natural Science Foundation of
China (82171101, 32171304); The Beijing Natural Science Foundation (7242019); The Capital Health
Research and Development of Special (2024-2-1082); and the Beijing Nova Program (H020420160130).
第一作者机构：[1]Peking Union Medical College Hospital, Beijing 100730, China[2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China[3]School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Qin Xiao,Hu Bi,Guo Lili,et al.Influence of Dextran Solution and Corneal Collagen Crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST In Vitro[J].Bioengineering (Basel, Switzerland).2024,11(11):doi:10.3390/bioengineering11111156.
APA：
Qin Xiao,Hu Bi,Guo Lili,Zhang Haixia,Li Lin...&Tian Lei.(2024).Influence of Dextran Solution and Corneal Collagen Crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST In Vitro.Bioengineering (Basel, Switzerland),11,(11)
MLA：
Qin Xiao,et al."Influence of Dextran Solution and Corneal Collagen Crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST In Vitro".Bioengineering (Basel, Switzerland) 11..11(2024)
