Pancreatic cancer (PC) is one of the most lethal human malignancies worldwide. Here, we demonstrated that xanthohumol (XN), the most abundant prenylated chalcone isolated from hops, inhibited the growth of cultured PC cells and their subcutaneous xenograft tumors. XN treatment was found to induce cell cycle arrest and apoptosis of PC cells (PANC-1, BxPC-3) by inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3) and expression of its downstream targeted genes cyclinD1, survivin, and Bcl-xL at the messenger RNA level, which involved in regulation of apoptosis and the cell cycle. Overall, our results suggested that XN presents a promising candidate therapeutic agent against human PC and the STAT3 signaling pathway is its key molecular target. (C) 2015 Elsevier Masson SAS. All rights reserved.
基金：
National Natural
Science Foundation of China (grant No.: 81200312) and the
Shanghai Key Laboratory of Pancreatic Diseases for open research
project (grant No.: 030134-05).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|2 区医学
小类|1 区药学2 区医学：研究与实验
JCR分区：
出版当年[2013]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ3PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Gastroenterol, Shanghai 200080, Peoples R China[*1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Gastroenterol, 100 Hai Ning Rd, Shanghai 200080, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[*1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Gastroenterol, 100 Hai Ning Rd, Shanghai 200080, Peoples R China
推荐引用方式(GB/T 7714)：
Jiang Weiliang,Zhao Senlin,Xu Ling,et al.The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer[J].BIOMEDICINE & PHARMACOTHERAPY.2015,73:40-47.doi:10.1016/j.biopha.2015.05.020.
APA：
Jiang, Weiliang,Zhao, Senlin,Xu, Ling,Lu, Yingying,Lu, Zhanjun...&Yang, Lijuan.(2015).The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer.BIOMEDICINE & PHARMACOTHERAPY,73,
MLA：
Jiang, Weiliang,et al."The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer".BIOMEDICINE & PHARMACOTHERAPY 73.(2015):40-47
医学