The aim of this paper was to describe the local flow pattern of carotid bifurcation model using instantaneous velocity fields acquired by particle image velocimetry (PIV) and numerical simulation. Solid modified tuning-fork averaged human carotid bifurcation (TF-AHCB) carotid bifurcation glass model was attached to a circuit driven by different static pressure gradient which produced different velocity. The working fluid consisted of glycerin and water mixture with a viscosity of 3.75mPa. s. Hollow glass spheres with a mean size of 10 mu m were used as tracer particles. Instantaneous velocity fields were obtained by means of PIV and shear stresses were calculated according to the velocity parameters. The same parameters were used for numerical simulation to get the velocity fields and wall shear stress distribution. The results showed that both by PIV and numerical simulation, a large flow separation with an anticlockwise rotating vortex formed at the outside wall of internal carotid artery (ICA) inside the model. The location and scope of the vortex changed with the velocity. The higher the velocity was, the smaller the vortex scope was, and the further the location to the bifurcation was. The flow pattern inside the model consists of large flow separation and anticlockwise vortex zones, the center of which locates near the sinus of ICA and are thought to be associated with the genesis of atherosclerosis. [ Hong B, Wang W, Wang X, Wang J, Ye M. Numerical Simulation to Get Flow Pattern in Modified Carotid Artery Bifurcation Model Using PIV. Life Sci J 2012; 9(3): 1296-1301] (ISSN: 1097-8135). http://www.lifesciencesite.com. 185