机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Beijing Institute of Otolaryngology, Capital Medical University, Beijing临床科室耳鼻咽喉-头颈外科研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Research Asia-Pacific, ALK A/S[3]State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, China
Conclusion: Specific immunoglobulin E (IgE) reactivity towards the major mugwort allergen Art v 1 is a good indicator for Art v sensitization. Allergens from the ragweed species Amb t and Amb a possibly share common IgE-binding epitopes. Objective: The aim of this study was to investigate the reactivity pattern of IgE in Chinese patients with weed pollen-induced allergic rhinitis. Methods: Sera from 50 weed pollen-induced allergic rhinitis patients were tested for specific serum IgE reactivity against allergenic extracts of mugwort (Artemisia vulgaris, Art v), short ragweed (Ambrosia artemisiifolia, Amb a), giant ragweed (Ambrosia trifida, Amb t), and single allergens of Art v 1, Art v 3, Amb a 1, and profilin. Results: Sera from 88% of the patients demonstrated positive specific IgE reactivity to Art v, and of these 82% were positive to Art v 1. Sera from 38% of the patients showed positive specific IgE reactivity to both ragweed species Amb t and Amb a. A strong correlation was found between the specific IgE levels of Amb t and Amb a. Of the Amb a IgE-positive patients, 38% were positive for Amb a 1. Of all patient sera tested, 12% were specific IgE-positive to profilin.
基金：
National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81025007]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30872846, 30973282]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7072017]; Beijing Education Committee Foundation [KZ200910025008]
第一作者机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Beijing Institute of Otolaryngology, Capital Medical University, Beijing
通讯作者：
通讯机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Beijing Institute of Otolaryngology, Capital Medical University, Beijing[*1]Beijing Inst Otolaryngol, 17 HouGouHuTong, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Han Demin,Lai Xuxin,Gjesing Birgitte,et al.The specific IgE reactivity pattern of weed pollen-induced allergic rhinitis patients[J].ACTA OTO-LARYNGOLOGICA.2011,131(5):533-538.doi:10.3109/00016489.2010.539265.
APA：
Han, Demin,Lai, Xuxin,Gjesing, Birgitte,Zhong, Nanshan,Zhang, Luo&Spangfort, Michael D..(2011).The specific IgE reactivity pattern of weed pollen-induced allergic rhinitis patients.ACTA OTO-LARYNGOLOGICA,131,(5)
MLA：
Han, Demin,et al."The specific IgE reactivity pattern of weed pollen-induced allergic rhinitis patients".ACTA OTO-LARYNGOLOGICA 131..5(2011):533-538
