Aims: The aim of study is to investigate the effect of nifedipine on Viral myocarditis in an animal model. Main methods: Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n = 10) or control (n = 10) group. The control group was fed by regular chow and the nifedipine group contained 0.01% of nifedipine. Mast cell density was Counted, and expressions of messenger RNAs of stem cell factor (SCF), matrix metalloproteinases (MMPs), pro-collagen 1, mast cell proteases, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were evaluated by RT-PCR. Key findings: The area of myocardial necrosis was smaller in the nifedipine vs the control group (mean +/- SD, 1.2 +/- 1.3% vs 3.8 +/- 1.8%, respectively, P<0.005). The mast cell density (count/mm(2)) was lower in the nifedipine vs the control group (mean SD, 0.23 +/- 0.16 vs 1.08 +/- 0.45, respectively, P<0.0005). The expressions of MMPs, mast cell proteases, TNF-alpha, IL-6, SCIF and pro-collagen I were lower in the nifeclipine group than in the control group (P<0.05). Significance: Nifedipine inhibited the activation of various participants in inflammatory and immune reactions in EMCV myocarditis. (C) 2009 Elsevier Inc. All rights reserved.
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外文
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中科院(CAS)分区：
出版当年[2008]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2023]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2007]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China[2]Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan
通讯作者：
通讯机构：[2]Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan[*1]Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawahara Cho Shogoin, Kyoto 6068507, Japan
推荐引用方式(GB/T 7714)：
Liu Wenling,Shimada Miho,Xiao Jie,et al.Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis[J].LIFE SCIENCES.2009,85(5-6):235-240.doi:10.1016/j.lfs.2009.05.018.
APA：
Liu, Wenling,Shimada, Miho,Xiao, Jie,Hu, Dayi&Matsumori, Akira.(2009).Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis.LIFE SCIENCES,85,(5-6)
MLA：
Liu, Wenling,et al."Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis".LIFE SCIENCES 85..5-6(2009):235-240
医学