机构：[1]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China,[2]School of Biomedical Engineering, Capital Medical University, Beijing, China,[3]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, CapitalMedical University, Beijing, China,研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beijing Tongren Hospital, Beihang University and Capital Medical University, Beijing, China,首都医科大学附属北京同仁医院首都医科大学附属同仁医院[5]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Purpose: The aim of this study was to provide a method to determine corneal nonlinear viscoelastic properties based on the output data of corneal visualization Scheimpflug technology (Corvis ST).Methods: The Corvis ST data from 18 eyes of 12 healthy humans were collected. Based on the air-puff pressure and the corneal displacement from the Corvis ST test of normal human eyes, the work done by the air-puff attaining the whole corneal displacement was obtained. By applying a visco-hyperelastic strain energy density function of the cornea, in which the first-order Prony relaxation function and the first-order Ogden strain energy were employed, the corneal strain energy during the Corvis ST test was calculated. Then the work done by the air-puff attaining the whole corneal displacement was completely regarded as the strain energy of the cornea. The identification of the nonlinear viscoelastic parameters was carried out by optimizing the sum of difference squares of the work and the strain energy using the genetic algorithm.Results: The visco-hyperelastic model gave a good fit to the data of corneal strain energy with time during the Corvis ST test (R-2 > 0.95). The determined Ogden model parameter mu ranged from 0.42 to 0.74 MPa, and alpha ranged from 32.76 to 55.63. The parameters A and tau in the first-order Prony function were 0.09-0.36 and 1.21-1.95 ms, respectively.Conclusion: It is feasible to determine the corneal nonlinear viscoelastic properties based on the corneal contour information and air-puff pressure of the Corvis ST test.
基金：
National Natural Science
Foundation of China (Nos. 31370952, 31470914, 31600758,
82171101, 32171304); Beijing Nova Program (Z181100006218099);
and the Open Research Fund from Beijing Advanced Innovation
Center for Big Data-Based Precision Medicine, Beijing Tongren
Hospital, Beihang University and Capital Medical University
(BHTR-KFJJ-202001).
第一作者机构：[1]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China,[2]School of Biomedical Engineering, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China,[2]School of Biomedical Engineering, Capital Medical University, Beijing, China,
推荐引用方式(GB/T 7714)：
Zhang Di,Zhang Haixia,Tian Lei,et al.Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST[J].FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.2021,9:doi:10.3389/fbioe.2021.771763.
APA：
Zhang, Di,Zhang, Haixia,Tian, Lei,Zheng, Yan,Fu, Caiyun...&Li, Lin.(2021).Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,9,
MLA：
Zhang, Di,et al."Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 9.(2021)
